CX model automatic chromatography separating unit
System components andcharacteristics
1.Automatic control system
The chromatogram working station that iscompiled on the basis of the advanced DCS distributed control strategy can realizecontrol and data collection of pumps,valves and various online detectors,conveniently complete the multi-column series and parallel operation andguarantee the stability and accuracy of technology.
2.Special online test system for traditional Chinese medicine
Including the test of regular process parameterssuch as flow, pressure, temperature, PH value(optional)and electricconductivity (optional) etc and real-time test of content of effective parts(orcomponents) of traditional Chinese medicine through ultravioletspectrum(optional)and near-infrared spectrum (optional).
3.Structure of chromatography column
The structure ofchromatography column is well designed with reasonable height-diameter rate.Theprecise inlet and outlet fluid distributing device is equipped with automaticfilling system and air and chromatography column and the regeneration effect offiller so as to provide guarantee for the high efficiency separation.
System control interface
The unit is specially designed, researched and developed for the purification of targeted compound in pharmaceutical industry. The preparative liquid chromatographic column has super high sample loading capacity which has provided reliable guarantee for enhance-ing the preparative quantity of purification products with lower cost .
Functions and characteristics
It is widely used for wastewater treatment,extractionand refining of protein, enzyme, monosaccharide, amylose and planteffectivecomponents etc.
The characteristics of chromatography separation are as follows:the operation condition is moderate (normal temperature, and normal pressuregenerally);the mixture can obtain multiple pure components at one time ; precise separation is available so as to obtain products of high purity. Combining modem computer automatic control technology and technical parameter online detection technology, the unit has upgraded and reformed the traditional manual chromatography equipment to enhance the reliability and repetition. The equipment is easy for magnifying the chromatography technology to solve the problem of industrialized production.
Application of chromatographic separation technology in the separation and purification of natural products
The chromatographic separation technology mostlyapplied in the traditional Chinese medicine separation and purification can be mainlydivided into adsorption chromatography and ion exchange chromatography.
The adsorptionchromatography includes reverse phase chromatography (C18 filler) and normalphase silica gel chromatography. The ion exchange chromatography is mainly usedforseparation and purification of compounds with electric charge.Currently,the chromatographic separation technology has playedmore and more functions inthe refining of effective components of Chinese medicine such as flavone,alkaloid, glycoside, organic acids and amylase etc.
Application of separation and purificationof natural products
Development of small-scale test technology, magnifying research of pilotscale
test technology, preparation of phytochemical standard products and contrasting
products .Widely suitable for separating phenol , aldehyde, alkaloid, amino
acid, steroid, terpene, flavone, quinine, organic acid, glycoside,
polysaccharide, nucleoside and pure products. Such as: paclitaxel, tea
polyphenol, ginkgoflavone, bamboo leave flavones and vitamin E, etc.